Lilli10779 wrote:Sometimes you flip the page and the image can look really funny and you know you'd messed up but its too late to fix... I hate when that happen to me.

If anyone knows the common root cause of "skewing" in drawings, I'd really like to know; this is a problem almost everything I draw suffers from. Many other artists out there seem to have the same problem, too.
As far as reading preference, personally I have none, but if different publishers want one or the other, then your best bet is probably to set up your working files so that it's easy to flip the art and re-position the text bubbles.